Silica-Coated Liposomes for Insulin Delivery | Zendy

Neelam Dwivedi | Zendy; Manickam Adhimoolam Arunagirinathan | Zendy; Somesh Sharma | Zendy; Jayesh Bellare | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Silica-Coated Liposomes for Insulin Delivery

Author(s) -

Neelam Dwivedi,

Manickam Adhimoolam Arunagirinathan,

Somesh Sharma,

Jayesh Bellare

Publication year - 2010

Publication title -

journal of nanomaterials

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.463

H-Index - 66

eISSN - 1687-4129

pISSN - 1687-4110

DOI - 10.1155/2010/652048

Subject(s) - materials science , liposome , insulin , chemical engineering , vesicle , lipid bilayer , bilayer , confocal microscopy , confocal , raman spectroscopy , coating , nanotechnology , membrane , biochemistry , chemistry , optics , medicine , physics , endocrinology , engineering

Liposomes coated with silica were explored as protein delivery vehicles for their enhanced stability and improved encapsulation efficiency. Insulin was encapsulated within the fluidic phosphatidylcholine lipid vesicles by thin film hydration at pH 2.5, and layer of silica was formed above lipid bilayer by acid catalysis. The presence of silica coating and encapsulated insulin was identified using confocal and electron microscopy. The native state of insulin present in the formulation was evident from Confocal Micro-Raman spectroscopy. Silica coat enhances the stability of insulin-loaded delivery vehicles. In vivo study shows that these silica coated formulations were biologically active in reducing glucose levels

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research