Open AccessRole of PPAR in Hepatic Carbohydrate Metabolism
Author(s) -
Annelies Peeters,
Myriam Baes
Publication year - 2010
Publication title -
ppar research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 49
eISSN - 1687-4765
pISSN - 1687-4757
DOI - 10.1155/2010/572405
Subject(s) - carbohydrate metabolism , regulator , lipid metabolism , peroxisome proliferator activated receptor , glucose homeostasis , metabolism , carbohydrate , endocrinology , medicine , peroxisome , homeostasis , chemistry , biology , biochemistry , receptor , gene , diabetes mellitus , insulin resistance
Tight control of storage and synthesis of glucose during nutritional transitions is essential to maintain blood glucose levels, a process in which the liver has a central role. PPARα is the master regulator of lipid metabolism during fasting, but evidence is emerging for a role of PPARα in balancing glucose homeostasis as well. By using PPARα ligands and PPARα(-/-) mice, several crucial genes were shown to be regulated by PPARα in a direct or indirect way. We here review recent evidence that PPARα contributes to the adaptation of hepatic carbohydrate metabolism during the fed-to-fasted or fasted-to-fed transition in rodents.
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