The S100B/RAGE Axis in Alzheimer's Disease | Zendy

Estelle Leclerc | Zendy; Emmanuel Sturchler | Zendy; Stefan W. Vetter | Zendy

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The S100B/RAGE Axis in Alzheimer's Disease

Author(s) -

Estelle Leclerc,

Emmanuel Sturchler,

Stefan W. Vetter

Publication year - 2010

Publication title -

cardiovascular psychiatry and neurology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.904

H-Index - 24

eISSN - 2090-0163

pISSN - 2090-0171

DOI - 10.1155/2010/539581

Subject(s) - rage (emotion) , medicine , disease , alzheimer's disease , neuroscience , pathology , psychology

Increasing evidence suggests that the small EF-hand calcium-binding protein S100B plays an important role in Alzheimer's disease. Among other evidences are the increased levels of both S100B and its receptor, the Receptor for Advanced Glycation Endproducts (RAGEs) in the AD diseased brain. The regulation of RAGE signaling by S100B is complex and probably involves other ligands including the amyloid beta peptide (A β ), the Advanced Glycation Endproducts (AGEs), or transtheyretin. In this paper we discuss the current literature regarding the role of S100B/RAGE activation in Alzheimer's disease.

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