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DNA samples from 339 Crohn's disease (CD) and 407 randomly selected controls from the Auckland (New Zealand) IBD project, were genotyped for five common single nucleotide polymorphisms in  IL-23R  (rs11805303, rs7517847, rs1343151, rs11209026, and rs10889677) and two in  IL-12B  (rs1363670 and rs6887695). While the  IL-12B  variants did not show an overall association and other  IL23R  variants led to minor changes in the risk of CD, rs1343151 and/or rs7517847 variants in the  IL-23R  gene strongly reduced the risk of developing CD at both allelic and genotype levels. A significantly decreased risk of first diagnosis of childhood CD was observed in individuals carrying the A allele of rs1343151, or between 17–40 y in individuals carrying the G allele in rs7517847 of  IL-23R . A significantly decreased risk of ileocolonic or structuring disease was observed in individuals carrying the A allele in either rs11209026 or rs1343151, or the G allele in rs7517847 of  IL-23R , and when such individuals did develop the disease, they were unlikely to require a bowel resection. Certain haplotypes very strongly modified risk. There was evidence for interactions of  IL-23R  variants with the  NOD2  wild-type (d/d) genotype. Down-regulating the function of the  IL-23R  gene may decrease CD risk in the normal population.

IL23RandIL12BSNPs and Haplotypes Strongly Associate with Crohn's Disease Risk in a New Zealand Population