Open AccessSuperacid-Induced Reactions of Nefopam
Author(s) -
Larecia Knoecer,
D. DeSchepper,
Douglas A. Klumpp
Publication year - 2010
Publication title -
organic chemistry international
Language(s) - English
Resource type - Journals
eISSN - 2090-2018
pISSN - 2090-200X
DOI - 10.1155/2010/496818
Subject(s) - superacid , chemistry , dication , friedel–crafts reaction , ring (chemistry) , analgesic , medicinal chemistry , organic chemistry , catalysis , psychiatry , psychology , molecule
The analgesic drug nefopam reacts in superacidic media to form a dicationic superelectrophiles by ring opening. The dication species is capable of reacting with arenes in Friedel-Crafts-type conversions. This chemistry is used to prepare novel derivatives of nefopam
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