Replication and Meta‐Analysis of 13,000 Cases Defines the Risk for Interleukin‐23 Receptor and Autophagy‐Related 16‐Like 1 Variants in Crohn’s Disease | Zendy

Lynn Cotterill | Zendy; Debbie Payne | Zendy; Scott Levison | Zendy; John McLaughlin | Zendy; Emma Wesley | Zendy; Mark Feeney | Zendy; H. Durbin | Zendy; Simon Lal | Zendy; Alistair Makin | Zendy; Simon Campbell | Zendy; Stephen A. Roberts | Zendy; Catherine O’Neill | Zendy; Cathryn Edwards | Zendy; William G. Newman | Zendy

Open Access

Replication and Meta‐Analysis of 13,000 Cases Defines the Risk for Interleukin‐23 Receptor and Autophagy‐Related 16‐Like 1 Variants in Crohn’s Disease

Author(s) -

Lynn Cotterill,

Debbie Payne,

Scott Levison,

John McLaughlin,

Emma Wesley,

Mark Feeney,

H. Durbin,

Simon Lal,

Alistair Makin,

Simon Campbell,

Stephen A. Roberts,

Catherine O’Neill,

Cathryn Edwards,

William G. Newman

Publication year - 2009

Publication title -

canadian journal of gastroenterology and hepatology

Language(s) - English

Resource type - Journals

eISSN - 2291-2797

pISSN - 2291-2789

DOI - 10.1155/2010/480458

Subject(s) - autophagy , crohn's disease , replication (statistics) , atg16l1 , disease , meta analysis , immunology , medicine , biology , virology , genetics , apoptosis

Variants in the interleukin-23 receptor (IL23R) and the autophagy-related 16-like 1 (ATG16L1) genes have been associated with an increased risk of Crohn's disease (CD). Both genes were identified through genome-wide association scans and subsequent studies have validated these associations. To assess the effect size of these variants, an independent case-control association study and meta-analysis were performed.

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