Genetics of Uveal Melanoma and Cutaneous Melanoma: Two of a Kind? | Zendy

Thomas van den Bosch | Zendy; Emine Kılıç | Zendy; Dion Paridaens | Zendy; Annelies de Klein | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Genetics of Uveal Melanoma and Cutaneous Melanoma: Two of a Kind?

Author(s) -

Thomas van den Bosch,

Emine Kılıç,

Dion Paridaens,

Annelies de Klein

Publication year - 2010

Publication title -

dermatology research and practice

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.456

H-Index - 29

eISSN - 1687-6113

pISSN - 1687-6105

DOI - 10.1155/2010/360136

Subject(s) - melanoma , medicine , carcinogenesis , oncology , dermatology , metastasis , adjuvant , cancer research , cancer

Cutaneous melanoma and uveal melanoma both derive from melanocytes but show remarkable differences in tumorigenesis, mode of metastatic spread, genetic alterations, and therapeutic response. In this review we discuss the differences and similarities along with the genetic research techniques available and the contribution to our current understanding of melanoma. The several chromosomal aberrations already identified prove to be very strong predictors of decreased survival in CM and UM patients. Especially in UM, where the overall risk of metastasis is high (45%), genetic research might aid clinicians in selecting high-risk patients for future systemic adjuvant therapies.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research