Transformation of a Cutaneous Follicle Center Lymphoma to a Diffuse Large B-Cell Lymphoma—An Unusual Presentation | Zendy

Joana Dias Coelho | Zendy; Filipa Diamantino | Zendy; Igor Santos Costa | Zendy; Pedro Farinha | Zendy; Paula Gameiro | Zendy; Marta Sebastião | Zendy; José Baptista | Zendy

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Transformation of a Cutaneous Follicle Center Lymphoma to a Diffuse Large B-Cell Lymphoma—An Unusual Presentation

Author(s) -

Joana Dias Coelho,

Filipa Diamantino,

Igor Santos Costa,

Pedro Farinha,

Paula Gameiro,

Marta Sebastião,

José Baptista

Publication year - 2010

Publication title -

case reports in medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.2

H-Index - 20

eISSN - 1687-9627

pISSN - 1687-9635

DOI - 10.1155/2010/296523

Subject(s) - lymphoma , medicine , biopsy , pathology , follicular hyperplasia , follicular lymphoma , diffuse large b cell lymphoma , cutaneous lymphoma , skin biopsy , mycosis fungoides

Primary cutaneous follicle center lymphoma (PCFCL) is characterized by a proliferation of follicle center cells in the skin. A definitive diagnosis is frequently delayed because of difficulties in interpretation of the histopathologic findings. It has an excellent prognosis with a 5-year survival over 95% and its risk of transformation has not been established. We describe a case report of man with a gastric diffuse large B-cell lymphoma (DLBCL) referred to our clinic because of nodules in the back that had gradually developed over a period of 10 years. A biopsy performed 3 years before was interpreted as reactive follicular hyperplasia. A new skin biopsy revealed a diffuse large B-cell lymphoma and immunoglobulin heavy chain gene rearrangements from the initial skin biopsy (PCBCL) and the DLBCL gastric biopsy were studied by polymerase chain reaction and an identical clonal rearrangement was detected which was highly suggestive of a transformation lymphoma.

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