Cytotoxic Properties of Titanocenyl Amides on Breast Cancer Cell Line MCF-7

A new titanocenyl amide containing flavone as pendant group has been synthesized by reaction of titanocenyl carboxylic acid chloride and 7-Aminoflavone and structurally characterized by spectroscopic methods. This species and eight previously synthesized titanocenyl amide complexes have been tested in breast adenocarcinoma cancer cell line, MCF-7. The functionalization of titanocene dichloride with amides enhances the cytotoxic activity in MCF-7. Two sets of titanocenyl amides can be identified, with IC 50 <100  μ M and IC 50 >100  μ M. The most cytotoxic species is Cp(CpCO-NH-C 6 H 4 -(CH 2 ) 2 CH 3 )TiCl 2 with an IC 50 of 24(2)  μ M, followed by Cp(CpCO-NH-C 6 H 4 -Br)TiCl 2 , IC 50 of 46(4)  μ M and Cp(CpCO-NH-C 6 H 4 -OCF 3 )TiCl 2 , IC 50 of 49(6)  μ M. There is no correlation between the nature of the para substituent on the phenyl ring and the cytotoxic properties on MCF-7 cell line.