Targeting Insulin and Insulin-Like Growth Factor Pathways in Epithelial Ovarian Cancer | Zendy

MarieClaude Beauchamp | Zendy; Amber Yasmeen | Zendy; Ariane Knafo | Zendy; Walter H. Gotlieb | Zendy

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Targeting Insulin and Insulin-Like Growth Factor Pathways in Epithelial Ovarian Cancer

Author(s) -

MarieClaude Beauchamp,

Amber Yasmeen,

Ariane Knafo,

Walter H. Gotlieb

Publication year - 2010

Publication title -

journal of oncology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.228

H-Index - 54

eISSN - 1687-8469

pISSN - 1687-8450

DOI - 10.1155/2010/257058

Subject(s) - medicine , ovarian cancer , insulin , cancer , carcinogenesis , insulin like growth factor , treatment modality , growth factor , epithelial ovarian cancer , oncology , therapeutic approach , cancer research , bioinformatics , biology , receptor , disease

Ovarian cancer is the most lethal of all gynecological malignancies, due in part to the diagnosis at an advanced stage caused by the lack of specific signs and symptoms and the absence of reliable tests for screening and early detection. Most patients will respond initially to treatment but about 70% of them will suffer a recurrence. Therefore, new therapeutic modalities are urgently needed to overcome chemoresistance observed in ovarian cancer patients. Evidence accumulates suggesting that the insulin/insulin growth factor (IGF) pathways could act as a good therapeutic target in several cancers, including ovarian cancer. In this paper, we will focus on the role of insulin/IGF in ovarian cancer tumorigenesis and treatment.

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