Protein Viability on Au Nanoparticles during an Electrospray and Electrostatic-Force-Directed Assembly Process | Zendy

Shun Mao | Zendy; Ganhua Lu | Zendy; Kehan Yu | Zendy; Junhong Chen | Zendy

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Protein Viability on Au Nanoparticles during an Electrospray and Electrostatic-Force-Directed Assembly Process

Author(s) -

Shun Mao,

Ganhua Lu,

Kehan Yu,

Junhong Chen

Publication year - 2010

Publication title -

journal of nanomaterials

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.463

H-Index - 66

eISSN - 1687-4129

pISSN - 1687-4110

DOI - 10.1155/2010/196393

Subject(s) - materials science , nanoparticle , carbon nanotube , nanotechnology , carbon nanotube field effect transistor , field effect transistor , electrospray , biosensor , transistor , chromatography , mass spectrometry , chemistry , voltage , physics , quantum mechanics

We study the protein viability on Au nanoparticles during an electrospray and electrostatic-force-directed assembly process, through which Au nanoparticle-antibody conjugates are assembled onto the surface of carbon nanotubes (CNTs) to fabricate carbon nanotube field-effect transistor (CNTFET) biosensors. Enzyme-linked immunosorbent assay (ELISA) and field-effect transistor (FET) measurements have been used to investigate the antibody activity after the nanoparticle assembly. Upon the introduction of matching antigens, the colored reaction from the ELISA and the change in the electrical characteristic of the CNTFET device confirm that the antibody activity is preserved during the assembly process

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