The Effect of Stereochemistry on Sodium Ion Complexation in Nucleoside-Metallacarborane Conjugates | Zendy

Agnieszka B. Olejniczak | Zendy; Jan Milecki | Zendy; Grzegorz Schroeder | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

The Effect of Stereochemistry on Sodium Ion Complexation in Nucleoside-Metallacarborane Conjugates

Author(s) -

Agnieszka B. Olejniczak,

Jan Milecki,

Grzegorz Schroeder

Publication year - 2010

Publication title -

bioinorganic chemistry and applications

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.865

H-Index - 35

eISSN - 1565-3633

pISSN - 1687-479X

DOI - 10.1155/2010/196064

Subject(s) - chemistry , conjugate , nucleoside , stereochemistry , ion , sodium , combinatorial chemistry , nucleoside analogue , organic chemistry , mathematical analysis , mathematics

Conjugates of purine and pyrimidine nucleosides: thymidine and 2′-deoxyguanosine with cobalt-metallacarborane were studied for their sodium ion complexing properties. Formation of stable complexes of 1 : 1 stoichiometry was proved by ESI MS spectroscopy and 23 Na NMR. Equilibrium constants and energies of complex formation were calculated. Complexation of alkali-metals by nucleoside-metallacarborane conjugates may affect the physicochemical and biological properties of the conjugates and should be taken into consideration during biological evaluation of these types of modifications.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research