ROCK as a Therapeutic Target of Diabetic Retinopathy | Zendy

Ryoichi Arita | Zendy; Yasuaki Hata | Zendy; Tatsuro Ishibashi | Zendy

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ROCK as a Therapeutic Target of Diabetic Retinopathy

Author(s) -

Ryoichi Arita,

Yasuaki Hata,

Tatsuro Ishibashi

Publication year - 2010

Publication title -

journal of ophthalmology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.818

H-Index - 40

eISSN - 2090-0058

pISSN - 2090-004X

DOI - 10.1155/2010/175163

Subject(s) - medicine , diabetic retinopathy , diabetes mellitus , pathogenesis , retinopathy , complication , population , ophthalmology , intensive care medicine , optometry , surgery , endocrinology , environmental health

The increasing global prevalence of diabetes is a critical problem for public health. In particular, diabetic retinopathy, a prevalent ocular complication of diabetes mellitus, causes severe vision loss in working population. A better understanding of the pathogenesis and the development of new pharmacologic treatments are needed. This paper describes the relevance between Rho/ROCK pathway and the pathogenesis of diabetic retinopathy from its early to late stages. Moreover, the therapeutic potential of ROCK inhibitor in the total management of diabetic retinopathy is discussed.

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