Antineoplastic Activity of New Transition Metal Complexes of 6‐Methylpyridine‐2‐carbaldehyde‐N(4)‐ethylthiosemicarbazone: X‐Ray Crystal Structures of [VO2(mpETSC)] and [Pt(mpETSC)Cl] | Zendy

Shadia A. Elsayed | Zendy; Ahmed M. ElHendawy | Zendy; Sahar I. Mostafa | Zendy; Bertrand J. JeanClaude | Zendy; Margarita Todorova | Zendy; Ian S. Butler | Zendy

Open Access

Antineoplastic Activity of New Transition Metal Complexes of 6‐Methylpyridine‐2‐carbaldehyde‐N(4)‐ethylthiosemicarbazone: X‐Ray Crystal Structures of [VO₂(mpETSC)] and [Pt(mpETSC)Cl]

Author(s) -

Shadia A. Elsayed,

Ahmed M. ElHendawy,

Sahar I. Mostafa,

Bertrand J. JeanClaude,

Margarita Todorova,

Ian S. Butler

Publication year - 2010

Publication title -

bioinorganic chemistry and applications

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.865

H-Index - 35

eISSN - 1565-3633

pISSN - 1687-479X

DOI - 10.1155/2010/149149

Subject(s) - algorithm , chemistry , computer science

New complexes of dioxovanadium(V), zinc(II), ruthenium(II), palladium(II), and platinum(II) with 6-methylpyridine-2-carbaldehyde-N(4)-ethylthiosemicarbazone (HmpETSC) have been synthesized. The composition of these complexes is discussed on the basis of elemental analyses, IR, Raman, NMR ( 1 H, 13 C, and 31 P), and electronic spectral data. The X-ray crystal structures of [VO 2 (mpETSC)] and [Pt(mpETSC)Cl] are also reported. The HmpETSC and its [Zn(HmpETSC)Cl 2 ] and [Pd(mpETSC)Cl] complexes exhibit antineoplastic activity against colon cancer human cell lines (HCT 116).

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