Eph Receptors and Ephrin Ligands: Important Players in Angiogenesis and Tumor Angiogenesis | Zendy

Birgit Mosch | Zendy; Bettina Reißenweber | Zendy; Christin Neuber | Zendy; Jens Pietzsch | Zendy

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Eph Receptors and Ephrin Ligands: Important Players in Angiogenesis and Tumor Angiogenesis

Author(s) -

Birgit Mosch,

Bettina Reißenweber,

Christin Neuber,

Jens Pietzsch

Publication year - 2010

Publication title -

journal of oncology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.228

H-Index - 54

eISSN - 1687-8469

pISSN - 1687-8450

DOI - 10.1155/2010/135285

Subject(s) - erythropoietin producing hepatocellular (eph) receptor , ephrin , angiogenesis , eph receptor a2 , receptor , medicine , cancer research , tumor microenvironment , microbiology and biotechnology , biology , tumor cells , receptor tyrosine kinase

Eph receptors and their ephrin ligands were identified in the late 1980's. Subsequently, they were linked to different physiological and pathophysiological processes like embryonic development, angiogenesis, and tumorigenesis. In this regard, recent work focused on the distribution and effects of Eph receptors and ephrins on tumor cells and tumor microenvironment. The purpose of this review is to outline the role of these molecules in physiological angiogenesis and pathophysiological tumor angiogenesis. Furthermore, novel therapeutical approaches are discussed as Eph receptors and ephrins represent attractive targets for antiangiogenic therapy.

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