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Brucella  species are the causative agents of one of the most prevalent zoonotic diseases: brucellosis. Infections by  Brucella  species cause major economic losses in agriculture, leading to abortions in infected animals and resulting in a severe, although rarely lethal, debilitating disease in humans.  Brucella  species persist as intracellular pathogens that manage to effectively evade recognition by the host's immune system. Sugar-modified components in the  Brucella  cell envelope play an important role in their host interaction.  Brucella  lipopolysaccharide (LPS), unlike  Escherichia coli  LPS, does not trigger the host's innate immune system.  Brucella  produces cyclic  β -1,2-glucans, which are important for targeting them to their replicative niche in the endoplasmic reticulum within the host cell. This paper will focus on the role of LPS and cyclic  β -1,2-glucans in  Brucella -mammalian infections and discuss the use of mutants, within the biosynthesis pathway of these cell envelope structures, in vaccine development.

Importance of Lipopolysaccharide and Cyclicβ-1,2-Glucans inBrucella-Mammalian Infections