In Vitro Synergy of Levofloxacin Plus Piperacillin/Tazobactam againstPseudomonas aeruginosa | Zendy

Vladimir Chachanidze | Zendy; Aixa Curbelo-Irizarry | Zendy; Deborah Ashcraft | Zendy; George A. Pankey | Zendy

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In Vitro Synergy of Levofloxacin Plus Piperacillin/Tazobactam againstPseudomonas aeruginosa

Author(s) -

Vladimir Chachanidze,

Aixa Curbelo-Irizarry,

Deborah Ashcraft,

George A. Pankey

Publication year - 2009

Publication title -

interdisciplinary perspectives on infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.593

H-Index - 28

eISSN - 1687-7098

pISSN - 1687-708X

DOI - 10.1155/2009/984934

Subject(s) - etest , piperacillin/tazobactam , levofloxacin , piperacillin , pseudomonas aeruginosa , tazobactam , microbiology and biotechnology , medicine , in vitro , antagonism , antibiotics , biology , bacteria , biochemistry , genetics , receptor

In vitro synergy testing using levofloxacin (LVX) plus piperacillin/tazobactam (TZP) was performed by Etest and time-kill assay (TKA) for 31 unique fluoroquinolone-resistant Pseudomonas aeruginosa isolates. The Etest method showed synergy for 9/31 (29%) of isolates, while TKA showed synergy with 14/31 (45%) of isolates. When comparing the Etest method and TKA, concordant results for synergy, antagonism, and indifference were obtained for 24/31 (77%) of the isolates tested.

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