Spectrophotometric Determination of Ceftiofur Hydrochloride UsingN-Bromosuccinimide andp-Dimethylaminobenzaldehyde | Zendy

V. Annapurna | Zendy; G. Jyothi | Zendy; C. Rambabu | Zendy; B. B. V. Sailaja | Zendy

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Spectrophotometric Determination of Ceftiofur Hydrochloride UsingN-Bromosuccinimide andp-Dimethylaminobenzaldehyde

Author(s) -

V. Annapurna,

G. Jyothi,

C. Rambabu,

B. B. V. Sailaja

Publication year - 2008

Publication title -

journal of chemistry

Language(s) - English

Resource type - Journals

eISSN - 2090-9063

pISSN - 2090-9071

DOI - 10.1155/2009/895948

Subject(s) - chemistry , n bromosuccinimide , ceftiofur , reagent , sulfanilamide , chromatography , hydrazone , nuclear chemistry , organic chemistry , cephalosporin , halogenation , antibiotics , biochemistry

Simple, accurate and reproducible UV-Visible spectrophotometric methods were established for the assay of ceftiofur based on the formation of oxidation and condensation products. Method A involves the oxidation of the ceftiofur (CEFT) with N-bromosuccinimide (NBS) and determination of the unconsumed NBS with p-N-methylaminophenol (PMAP)-sulfanilamide (SA) (PMAP-SA) reagent. Method B includes the determination of unreacted NBS using a known excess of celestine blue (CB) and measuring the remaining dye. Condensation of p-dimethylaminobenzaldehyde (PDAB) with the drug was the basis of method C. Determination of CEFT in bulk form and in pharmaceutical formulations was also incorporated

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