Synthesis, Characterization and Antimicrobial Activity of Metal Chelates of 5-[4-Chloro phenyl(1, 3, 4)thiadiazol-2-ylamino methylene]-8-hydroxy quinoline | Zendy

Divyesh K. Patel | Zendy; Arun Kumar Singh | Zendy

Open Access

Synthesis, Characterization and Antimicrobial Activity of Metal Chelates of 5-[4-Chloro phenyl(1, 3, 4)thiadiazol-2-ylamino methylene]-8-hydroxy quinoline

Author(s) -

Divyesh K. Patel,

Arun Kumar Singh

Publication year - 2009

Publication title -

journal of chemistry

Language(s) - English

Resource type - Journals

eISSN - 2090-9063

pISSN - 2090-9071

DOI - 10.1155/2009/894156

Subject(s) - quinoline , methylene , chelation , metal , chemistry , antifungal , nuclear chemistry , transition metal , stoichiometry , sodium bicarbonate , ligand (biochemistry) , elemental analysis , inorganic chemistry , medicinal chemistry , organic chemistry , catalysis , medicine , biochemistry , receptor , dermatology

5-Chloromethyl-8-quinolinol was condensed stoichiometrically with 5-(4-chlorophenyl)-(1,3,4) thiadiazol-2-ylamine in the presence of sodium bicarbonate. The resulting 5-[4-chlorophenyl-(1,3,4)thiadiazol-2-ylamino methylene]-8-quinolinol (CTAQ) was characterized by elemental analysis and spectral studies. The transition metal chelates viz. Cu2+, Ni2+, Co2+, Mn2+ and Zn2+ of CTAQ were prepared and characterized by metal-ligand (M:L) ratio, IR and reflectance spectroscopies and magnetic properties. The antifungal activity of CTAQ and its metal chelates was screened against various fungi. The results show that all these samples are good antifungal agents

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