Design, Synthesis and Evaluation of Schiff’s Bases of 4-Chloro-3-coumarin aldehyde as Antimicrobial Agents | Zendy

Shriram Bairagi | Zendy; Ashok Bhosale | Zendy; Meenakshi N. Deodhar | Zendy

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Design, Synthesis and Evaluation of Schiff’s Bases of 4-Chloro-3-coumarin aldehyde as Antimicrobial Agents

Author(s) -

Shriram Bairagi,

Ashok Bhosale,

Meenakshi N. Deodhar

Publication year - 2008

Publication title -

journal of chemistry

Language(s) - English

Resource type - Journals

eISSN - 2090-9063

pISSN - 2090-9071

DOI - 10.1155/2009/874389

Subject(s) - antimicrobial , coumarin , aldehyde , yield (engineering) , chemistry , solvent , gram , bacteria , proton nmr , gram negative bacteria , in vitro , combinatorial chemistry , organic chemistry , escherichia coli , biochemistry , biology , materials science , catalysis , genetics , gene , metallurgy

Chloro-2-oxo-2H-chromene-3-carbaldehyde (2) was reacted with different anilines in rectified spirit as solvent to yield a series of the title compounds i.e . 4-chloro-3-((substituted-phenylimino) methyl)-2H-chromen-2- one (3a-i) . These compounds were charaterised on the basis of their spectral (IR, 1 H NMR) data and evaluated for antimicrobial activity in vitro against gram positive and gram negative bacteria and fungi. Compound 3C was found to be most active with an MIC of 15 µg /mL against all the tested organisms.

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