Preparation and In Vitro Behavior of a Poly(lactic acid)‐Fiber/Hydroxyapatite Composite Sheet | Zendy

Yasuhiro Tanimoto | Zendy; Norihiro Nishiyama | Zendy

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Preparation and In Vitro Behavior of a Poly(lactic acid)‐Fiber/Hydroxyapatite Composite Sheet

Author(s) -

Yasuhiro Tanimoto,

Norihiro Nishiyama

Publication year - 2009

Publication title -

advances in materials science and engineering

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.356

H-Index - 42

eISSN - 1687-8442

pISSN - 1687-8434

DOI - 10.1155/2009/827241

Subject(s) - materials science , composite number , fiber , apatite , lactic acid , composite material , polylactic acid , simulated body fluid , chemical engineering , scanning electron microscope , polymer , genetics , biology , bacteria , engineering

This paper describes the processing and in vitro behavior of a poly(lactic acid) (PLA)-fiber/hydroxyapatite (HA) composite sheet consisting of a knitted PLA-fiber sheet and HA powder for bone tissue engineering. Type I collagen was used as a binding agent to combine the PLA fibers and the HA powder. Precipitate formation in Hanks' balanced salt (HBS) solution was monitored to evaluate the in vitro apatite formation ability of the PLA-fiber/HA composite sheet. Precipitate formation was observed on the surface of the PLA-fiber/HA composite sheet after immersion in HBS solution for only 1 day, while no precipitate formation was observed on the PLA-fiber sheet without HA as a control. In conclusion, a PLA-fiber/HA composite sheet for use as a scaffold was successfully prepared. Within the limitations of this investigation, we confirmed that the PLA-fiber/HA composite sheet has a high apatite formation activity compared with the PLA-fiber sheet and represents a promising material for use as a scaffold

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