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Although legionnaires' disease frequently is acquired in health care institutions, little is known about the occupational risk of  Legionella  infection among health care workers. The aim of the present cross-sectional study was to analyse antibody levels among exposed hospital workers and to determine the correlation between antibodies to  Legionella  and self-reported symptoms. The study included 258 hospital employees and a reference group of 708 healthy blood donors.  Hospital workers had a higher prevalence of  Legionella  antibody titres (≥1 : 128) than blood donors (odds ratio 3.4; 95% CI 2.4–4.8). Antibody levels were not higher among staff members at risk of frequent aerosol exposure than among less exposed employees. There was no consistent association between a history of influenza-like symptom complex and the presence of antibodies.  The results indicate that hospital workers have a higher risk of  Legionella  infections than the general population. However, since no excess morbidity was associated with seropositivity, most  Legionella  infections may be asymptomatic.

LegionellaAntibodies in a Danish Hospital Staff with Known Occupational Exposure