Open AccessSynthesis, spectral characterization and antibacterial studies of palladium(II) complexes of heterocyclic thiones
Author(s) -
Syed Ahmed Tirmizi,
Shafqat Nadeem,
Abdul Hameed,
Muhammad Hamid Sarwar Wattoo,
Aneela Anwar,
Zameer Ahmed Ansari,
Saeed Ahmad
Publication year - 2009
Publication title -
spectroscopy an international journal
Language(s) - English
Resource type - Journals
eISSN - 1875-922X
pISSN - 0712-4813
DOI - 10.1155/2009/763231
Subject(s) - chemistry , palladium , medicinal chemistry , proton nmr , sulfur , methanol , carbon 13 nmr , molar ratio , antibacterial activity , nuclear chemistry , stereochemistry , organic chemistry , catalysis , biology , bacteria , genetics
Reactions of K 2 [PdCl 4 ] with heterocyclic thiones in molar ratios of 1:2 and 1:4 in water-methanol medium yielded the palladium(II) complexes with the general formula of either [Pd(L)Cl 2 ], [Pd(L) 2 ]Cl 2 or [Pd(L) 4 ]Cl 2 where L ═ Imidazolidine-2-thione (Imt), 2-Mercaptopyridine (Mpy), 2-Mercaptopyrimidine (Mpm), 6-Mercaptopurine (6-Mp) and Thionicotinamide (Tna). The complexes were characterized by elemental analysis and spectroscopic (IR, 1 H and 13 C NMR) methods. An upfield shift in the >C═S resonance of thiones in 13 C NMR and downfield shift in N–H or aromatic proton resonances in 1 H NMR are consistent with the sulfur coordination to palladium(II). The complexes were screened for antibacterial activity, and the results showed that the complexes exhibited moderate activities as compared to that of a standard drug.
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