Diagnostic Algorithm Using a Sensitive Broth Culture Method for Detection ofClostridium difficileToxin from Stool Samples | Zendy

Paul Bayardelle | Zendy

Open Access

Diagnostic Algorithm Using a Sensitive Broth Culture Method for Detection ofClostridium difficileToxin from Stool Samples

Author(s) -

Paul Bayardelle

Publication year - 2009

Publication title -

canadian journal of infectious diseases and medical microbiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.634

H-Index - 38

eISSN - 1918-1493

pISSN - 1712-9532

DOI - 10.1155/2009/573898

Subject(s) - clostridium difficile , glutamate dehydrogenase , neutralization , microbiology and biotechnology , feces , clostridiaceae , biology , medicine , toxin , virology , antibiotics , glutamate receptor , biochemistry , virus , receptor

The two-step glutamate dehydrogenase antigencytotoxicity neutralization assay algorithm has been found to be reliable for the diagnosis of toxigenic Clostridium difficile. However, the high sensitivity of the screening method is compromised by the relative low sensitivity of the second step, the direct cytotoxin neutralization assay (DCNA) using a fecal filtrate. The objective of the present study was to compare the DCNA with an indirect cytotoxin neutralization assay (ICNA).

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