Open AccessIs Chronic Inflammation a Possible Cause of Obesity-Related Depression?
Author(s) -
Magdalena OlszaneckaGlinianowicz,
Barbara ZahorskaMarkiewicz,
Piotr Kocełak,
Joanna Janowska,
Elżbieta Semik-Grabarczyk,
Tomasz Wikarek,
Wojciech Gruszka,
Piotr Dąbrowski
Publication year - 2009
Publication title -
mediators of inflammation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.37
H-Index - 97
eISSN - 1466-1861
pISSN - 0962-9351
DOI - 10.1155/2009/439107
Subject(s) - depression (economics) , obesity , leptin , adipokine , medicine , inflammation , mood , tumor necrosis factor alpha , endocrinology , beck depression inventory , psychology , clinical psychology , psychiatry , anxiety , economics , macroeconomics
Adult obesity has been associated with depression, especially in women. Whether depression leads to obesity or obesity causes depression is unclear. Chronic inflammation is observed in obesity and depression. In 63 obese women without additional diseases depression level was assessed with the Beck's questionnaire. After evaluation of depression level study group was divided into groups according to the mood status (A—without depression, B—mild depression, and C—severe depression), and serum concentration of TNF- α , sTNFs, leptin, and IL-6 were measured by ELISA. No differences in age, body mass, BMI, and body composition were observed in study groups. We did not observe differences of serum concentrations of TNF- α , sTNFRs, leptin, and IL-6 between subgroup A and subgroups B and C. It seems that circulating adipokines did not exert influence on depression levels in obese women.
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