Open AccessMyopathy with Concurrent Tadalafil and Simvastatin
Author(s) -
Maria Pia Gargante,
Marco Vacante,
Cristina Russo,
Mariano Malaguarnera
Publication year - 2009
Publication title -
case reports in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.2
H-Index - 20
eISSN - 1687-9627
pISSN - 1687-9635
DOI - 10.1155/2009/378287
Subject(s) - simvastatin , tadalafil , myalgia , medicine , myopathy , pharmacology , erectile dysfunction
A 48-year-old man, using statin, was admitted to hospital with progressive myalgia after consumption of tadalafil and simvastatin. Muscle pain and penile erection disappeared seven days after interruption of therapy. This case demonstrates the interaction of tadalafil with simvastatin resulting in myopathy. Muscle damage could be attributed to the common metabolic way of these two drugs which is cytochrome P450 isoenzyme system.
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