Effect of Microwave Radiation on Enzymatic and Chemical Peptide Bond Synthesis on Solid Phase | Zendy

Alessandra Basso | Zendy; Loris Sinigoi | Zendy; Lucia Gardossi | Zendy; Sabine L. Flitsch | Zendy

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Effect of Microwave Radiation on Enzymatic and Chemical Peptide Bond Synthesis on Solid Phase

Author(s) -

Alessandra Basso,

Loris Sinigoi,

Lucia Gardossi,

Sabine L. Flitsch

Publication year - 2009

Publication title -

international journal of peptides

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.239

H-Index - 25

eISSN - 1687-9775

pISSN - 1687-9767

DOI - 10.1155/2009/362482

Subject(s) - thermolysin , microwave , peptide synthesis , peptide , peptide bond , kinetics , microwave irradiation , enzyme , chemical synthesis , phase (matter) , chemistry , solid phase synthesis , combinatorial chemistry , materials science , catalysis , biochemistry , organic chemistry , in vitro , computer science , physics , trypsin , quantum mechanics , telecommunications

Peptide bond synthesis was performed on PEGA beads under microwave radiations. Classical chemical coupling as well as thermolysin catalyzed synthesis was studied, and the effect of microwave radiations on reaction kinetics, beads' integrity, and enzyme activity was assessed. Results demonstrate that microwave radiations can be profitably exploited to improve reaction kinetics in solid phase peptide synthesis when both chemical and biocatalytic strategies are used.

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