The HPV Cellular Transactivator Brn-3a Can Be Used to Predict Cervical Adenocarcinoma and Squamous Carcinoma Precancer Lesions in the Developed and Developing Worlds | Zendy

Daniel Ndisang | Zendy; Felipe Rinald Barbosa Lorenzato | Zendy; Michael Sindos | Zendy; A. Khan | Zendy; Albert Singer | Zendy; David S. Latchman | Zendy

Open Access

The HPV Cellular Transactivator Brn-3a Can Be Used to Predict Cervical Adenocarcinoma and Squamous Carcinoma Precancer Lesions in the Developed and Developing Worlds

Author(s) -

Daniel Ndisang,

Felipe Rinald Barbosa Lorenzato,

Michael Sindos,

A. Khan,

Albert Singer,

David S. Latchman

Publication year - 2009

Publication title -

obstetrics and gynecology international

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.648

H-Index - 13

eISSN - 1687-9589

pISSN - 1687-9597

DOI - 10.1155/2009/359457

Subject(s) - transactivation , medicine , cervix , adenocarcinoma , basal cell , cancer research , pathology , cervical cancer , cancer , gene expression , gene , biology , biochemistry

The cellular transactivator Brn-3a has previously been shown to be expressed at elevated levels in the cervix of women with squamous cell carcinoma of the cervix (SCC) and to activate the expression of HPV E6 mRNA. In this study, we show that common and rare cervical precancer lesions, including those of adenocarcinoma (AC), which are usually difficult to diagnose using classical procedures, also expressed high levels of Brn-3a and can be diagnosed by measuring the levels of Brn-3a and E6 mRNAs.

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