Open AccessSynthesis, Cytotoxic Activity, and DNA Binding Properties of Copper (II) Complexes with Hesperetin, Naringenin, and Apigenin
Author(s) -
MingXiong Tan,
Zhu Jin-chan,
YingMing Pan,
ZhenFeng Chen,
Hong Liang,
Huagang Liu,
HengShan Wang
Publication year - 2009
Publication title -
bioinorganic chemistry and applications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.865
H-Index - 35
eISSN - 1565-3633
pISSN - 1687-479X
DOI - 10.1155/2009/347872
Subject(s) - hesperetin , naringenin , chemistry , apigenin , cytotoxic t cell , copper , pharmacology , biochemistry , flavonoid , organic chemistry , antioxidant , in vitro , medicine
Complexes of copper (II) with hesperetin, naringenin, and apigenin of general composition [CuL 2 (H 2 O) 2 ] ⋅ nH 2 O ( 1 – 3 ) have been synthesized and characterized by elemental analysis, UV-Vis, FT-IR, ESI-MS, and TG-DTG thermal analysis. The free ligands and the metal complexes have been tested in vitro against human cancer cell lines hepatocellular carcinoma (HepG-2), gastric carcinomas (SGC-7901), and cervical carcinoma (HeLa). Complexes 1 and 3 were found to exhibit growth inhibition of SGC-7901 and HepG2 cell lines with respect to the free ligands; the inhibitory rate of complex 1 is 43.2% and 43.8%, while complex 3 is 46% and 36%, respectively. The interactions of complex 1 and its ligand Hsp with calf thymus DNA were investigated by UV-Vis, fluorescence, and CD spectra. Both complex 1 and Hsp were found to bind DNA in intercalation modes, and the binding affinity of complex 1 was stronger than that of free ligand.
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