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Breast cancer is the most prominent cancer among females in the United States. There are a number of risk factors associated with development of breast cancer, including consumption of a high-fat diet and obesity. Plasminogen activator inhibitor-1 (PAI-1) is a cytokine upregulated in obesity whose expression is correlated with a poor prognosis in breast cancer. As a key mediator of adipogenesis and regulator of adipokine production, peroxisome proliferator-activated receptor- γ  (PPAR- γ ) is involved in PAI-1 expression from adipose tissue. We summarize the current knowledge linking PPAR- γ  and PAI-1 expression to high-fat diet and obesity in the risk of breast cancer.

ppar research

Obesity and Breast Cancer: The Roles of Peroxisome Proliferator-Activated Receptor-<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mi>γ</mml:mi></mml:math>and Plasminogen Activator Inhibitor-1

Obesity and Breast Cancer: The Roles of Peroxisome Proliferator-Activated Receptor-γand Plasminogen Activator Inhibitor-1