Open AccessThe Kinetics of Ampicillin Release from Hydroxyapatite for Bones Regeneration
Author(s) -
Giovanilton Ferreira da Silva,
José Sílvio Veras Albuquerque,
Caroliny Gomes de Oliveira,
Ricardo Emílio Ferreira Quevedo Nogueira,
Andrea Lopes de Oliveira Ferreira
Publication year - 2009
Publication title -
international journal of chemical engineering
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.309
H-Index - 25
eISSN - 1687-8078
pISSN - 1687-806X
DOI - 10.1155/2009/273808
Subject(s) - ampicillin , adsorption , antibiotics , controlled release , kinetics , drug delivery , chemistry , biomedical engineering , materials science , nanotechnology , medicine , biochemistry , organic chemistry , physics , quantum mechanics
Semisynthetic beta-lactam antibiotics are among the most used pharmaceuticals. Their use in veterinary and human medicine is in continuous expansion. There is a growing need for developing bioactive implants. Advantages of implantable drug delivery tools can include high release efficiency, precise dose control, low toxicity, and allow to overcome disadvantages connected with conventional methods. In this respect, hydroxyapatite (HA) is an elective material. It enables to produce architectures similar to those of real bones. Here we studied a kinetic model to describe ampicillin release from HA. In the course of adsorption experiment, ampicillin was dissolved, maintained at 30∘C and shaken at 60 strokes/minute. Samples were withdrawn periodically for analysis and then returned to the mixture. Adsorbed amounts were measured by the difference of the concentration of the antibiotics before and after adsorption using UV adsorption at 225 nm. The aim of this work was to evaluate its application as ampicillin delivery carrier
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