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Purpose . To describe the presence of secretory leukocyte protease inhibitor (SLPI), a cationic peptide with antimicrobial and antiprotease activity in the innate immune reaction in a rat model of  Staphylococcus aureus  keratitis.   Methods . Forty female Lewis rats were divided into 2 groups: the infectious keratitis and the epithelial defect groups. Eyes were processed for immunohistochemical studies for SLPI, interleukin-1, interleukin-6, tumor necrosis factor-alpha, and matrix metalloproteinase-8.   Results . Immunohistochemical studies confirmed high levels of SLPI, IL-1, IL-6, TNF- α , and MMP-8 expression in eyes with  S. aureus  keratitis and with epithelial defects, in contrast to undetectable SLPI expression in the normal control corneas.   Conclusions . To our knowledge, this paper is the first to demonstrate the presence of SLPI with increased amounts of proinflammatory cytokines in inflamed and infected corneas.

Secretory Leukoprotease Inhibitor: A Native Antimicrobial Protein in the Innate Immune Response in a Rat Model ofS. aureusKeratitis