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Uvaria chamae P. Beauv and Clerodendron splendens A Cheval are known to have various medicinal and therapeutic properties. Their anti- inflammatory and oxytocic properties were assessed in this study. The extracts and aspirin were found to inhibit carrageenan-induced paw oedema on albino rats and mice with a strong activity in aspirin having (80.43 %) inhibition while U. chamae and C. splendens have 69.57% and 47.83% inhibition respectively. The plants extract exhibition and uterine contraction activity on guinea pig. Phytochemical studies on the plants revealed the presence of bioactive components comprising flavonoids (0.70 - 5.70 mg. 100 g-1), alkaloids (0.81- 5.40 mg. 100 g-1), tannins (0.40 - 3.60 mg. 100 g-1), saponins (0.38 - 2.10 mg. 100 g-1) and phenols (0.08 - 0.10 mg. 100 g-1). These bioactive compounds may be responsible for the medicinal properties of U. chaemae and C. splendens that form the basis of their use in herbal medicine in Nigeria.

Phytochemical Composition and Biological Activities of Uvaria chamae and Clerodendoron splendens