Interleukin-10: A Key Cytokine in Depression? | Zendy

Susana Roque | Zendy; Margarida CorreiaNeves | Zendy; Ana Mesquita | Zendy; Joana Almeida Palha | Zendy; Nuno Sousa | Zendy

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Interleukin-10: A Key Cytokine in Depression?

Author(s) -

Susana Roque,

Margarida CorreiaNeves,

Ana Mesquita,

Joana Almeida Palha,

Nuno Sousa

Publication year - 2009

Publication title -

cardiovascular psychiatry and neurology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.904

H-Index - 24

eISSN - 2090-0163

pISSN - 2090-0171

DOI - 10.1155/2009/187894

Subject(s) - proinflammatory cytokine , cytokine , depression (economics) , antidepressant , notice , medicine , interleukin 6 , immunology , psychiatry , bioinformatics , inflammation , anxiety , biology , political science , economics , law , macroeconomics

An increasing body of evidence implicates proinflammatory cytokines in psychiatric disorders, namely, in depression. Of notice, recent studies showed that anti-inflammatory cytokines, such as IL-10, also modulate depressive-like behavior. In this article, we propose that the anti-inflammatory cytokine IL-10 is a putative link between two of the most widely reported phenomenon observed in depressed patients: the disruption of the hypothalamic-pituitary-adrenal axis and the imbalanced production of cytokines. If so, IL-10 might represent a novel target for antidepressant therapy.

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