Role of Plasmapheresis in the Treatment of Severe Pruritus in Pregnant Patients with Primary Biliary Cirrhosis: Case Reports | Zendy

Alallam Alallam | Zendy; David Barth | Zendy; E. Jenny Heathcote | Zendy

Open Access

Role of Plasmapheresis in the Treatment of Severe Pruritus in Pregnant Patients with Primary Biliary Cirrhosis: Case Reports

Author(s) -

Alallam Alallam,

David Barth,

E. Jenny Heathcote

Publication year - 2008

Publication title -

canadian journal of gastroenterology

Language(s) - English

Resource type - Journals

eISSN - 1916-7237

pISSN - 0835-7900

DOI - 10.1155/2008/969826

Subject(s) - plasmapheresis , medicine , itching , primary biliary cirrhosis , pregnancy , cholestasis , cholestyramine , ursodeoxycholic acid , surgery , pediatrics , immunology , antibody , cholesterol , biology , genetics

Primary biliary cirrhosis (PBC) may be associated with pruritus and, when present, may be accentuated during pregnancy. Several therapeutic modalities have been used to control itching caused by cholestasis, with variable responses. Drug therapies are ill-advised, particularly in early pregnancy. Plasmapheresis has been successful in controlling pruritus in patients with cholestasis. The use of plasmapheresis to alleviate severe life-threatening pruritus during pregnancy is reported in two patients with PBC.

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