Open AccessA Novel, One-Step Palladium and Phenylsilane Activated Amidation from Allyl Ester on Solid Support
Author(s) -
Zheming Ruan,
Katy Van Kirk,
Christopher B. Cooper,
R. Michael Lawrence
Publication year - 2008
Publication title -
research letters in organic chemistry
Language(s) - English
Resource type - Journals
eISSN - 1687-6938
pISSN - 1687-6865
DOI - 10.1155/2008/696090
Subject(s) - phenylsilane , catalysis , palladium , chemistry , solid acid , organic chemistry , reaction conditions , combinatorial chemistry
The direct conversion of solid-supported carboxylic acid allyl esters to carboxamides through the use of phenylsilane and catalytic Pd(PPh3)4 under mild reaction conditions is reported. The use of this methodology for the generation of a 48 compound solid-phase array is described herein.
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