VSL#3 Probiotic Upregulates Intestinal Mucosal Alkaline Sphingomyelinase and Reduces Inflammation | Zendy

Isaac Soo | Zendy; Karen Madsen | Zendy; Qassim Tejpar | Zendy; Beate C. Sydora | Zendy; Richard W. Sherbaniuk | Zendy; Benedetta Cinque | Zendy; Luisa Di Marzio | Zendy; Maria Grazia Cifone | Zendy; Claudio Desimone | Zendy; Richard N. Fedorak | Zendy

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VSL#3 Probiotic Upregulates Intestinal Mucosal Alkaline Sphingomyelinase and Reduces Inflammation

Author(s) -

Isaac Soo,

Karen Madsen,

Qassim Tejpar,

Beate C. Sydora,

Richard W. Sherbaniuk,

Benedetta Cinque,

Luisa Di Marzio,

Maria Grazia Cifone,

Claudio Desimone,

Richard N. Fedorak

Publication year - 2008

Publication title -

canadian journal of gastroenterology

Language(s) - English

Resource type - Journals

eISSN - 1916-7237

pISSN - 0835-7900

DOI - 10.1155/2008/520383

Subject(s) - sphingomyelin , ulcerative colitis , sphingomyelin phosphodiesterase , colitis , ceramide , acid sphingomyelinase , medicine , gastroenterology , ileum , probiotic , sphingosine , chemistry , biology , biochemistry , apoptosis , cholesterol , disease , bacteria , genetics , receptor

Alkaline sphingomyelinase, an enzyme found exclusively in bile and the intestinal brush border, hydrolyzes sphingomyelin into ceramide, sphingosine and sphingosine-1-phosphate, thereby inducing epithelial apoptosis. Reduced levels of alkaline sphingomyelinase have been found in premalignant and malignant intestinal epithelia and in ulcerative colitis tissue. Probiotic bacteria can be a source of sphingomyelinase.

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