The Amphiphilic Self‐Assembling Peptide EAK16‐I as a Potential Hydrophobic Drug Carrier
Author(s) -
Jing Wang,
Fushan Tang,
Feng Li,
Juan Lin,
Yinghui Zhang,
LinFang Du,
XiaoJun Zhao
Publication year - 2008
Publication title -
journal of nanomaterials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.463
H-Index - 66
eISSN - 1687-4129
pISSN - 1687-4110
DOI - 10.1155/2008/516286
Subject(s) - pyrene , amphiphile , vesicle , aqueous solution , peptide , membrane , phosphatidylcholine , fluorescence , materials science , drug carrier , hydrophobic effect , colloid , biophysics , micelle , chemical engineering , drug delivery , organic chemistry , chemistry , copolymer , nanotechnology , biochemistry , phospholipid , polymer , physics , quantum mechanics , engineering , biology
It is crucial for hydrophobic drugs to be dissolved and stabilized by carriers in aqueous systems and then to be delivered into target cells. An amphiphilic self-assembling peptide EAK16-I (Ac-AEAKAEAKAEAKAEAK-NH2) is reported here to be able to stabilize a model hydrophobic compound, pyrene, in aqueous solution, resulting in the formation of colloidal suspensions. Egg phosphatidylcholine (EPC) vesicles are used as plasma membranes mimic. Fluorescence data shows that the pyrene is presented in the crystalline form when stabilized by EAK16-I and molecularly migrates from its peptide encapsulations into the membrane bilayers of EPC vesicles when the suspension is mixed with EPC vesicles. Furthermore, the release rate can be controlled by changing peptide-to-pyrene ratio, and the higher ratios lead to the slower release rates due to a thicker encapsulation on the pyrene microcrystals. This demonstrates that EAK16-I, as a promising nanobiomaterial, has the potential to be a hydrophobic compounds carrier
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