A bifunctional archaeal protein that is a component of 30S ribosomal subunits and interacts with C/D box small RNAs | Zendy

Andrea Ciammaruconi | Zendy; Stefania Gorini | Zendy; Paola Londei | Zendy

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A bifunctional archaeal protein that is a component of 30S ribosomal subunits and interacts with C/D box small RNAs

Author(s) -

Andrea Ciammaruconi,

Stefania Gorini,

Paola Londei

Publication year - 2007

Publication title -

archaea

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.8

H-Index - 40

eISSN - 1472-3654

pISSN - 1472-3646

DOI - 10.1155/2008/472786

Subject(s) - 30s , ribosomal protein , ribosome , ribosomal rna , archaea , biology , protein subunit , thermophile , eukaryotic large ribosomal subunit , biochemistry , euryarchaeota , rna , enzyme , gene

We have identified a novel archaeal protein that apparently plays two distinct roles in ribosome metabolism. It is a polypeptide of about 18 kDa (termed Rbp18) that binds free cytosolic C/D box sRNAs in vivo and in vitro and behaves as a structural ribosomal protein, specifically a component of the 30S ribosomal subunit. As Rbp18 is selectively present in Crenarcheota and highly thermophilic Euryarchaeota, we propose that it serves to protect C/D box sRNAs from degradation and perhaps to stabilize thermophilic 30S subunits.

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