Synthesis and Biological Activity of Some new 2-Heterocyclic/acyclic amino/4'-acetamidophenoxy-3-(4-chloro-phenyl)-3, 4-dihydrobenzo[e]- [1,3,2]oxazaphosphinine 2-sulfides | Zendy

K. R. Kishore Kumar Reddy | Zendy; Gandavaram Syam Prasad | Zendy; Manjeet Kumar | Zendy; C. Suresh Reddy | Zendy; C. Naga Raju | Zendy

Open Access

Synthesis and Biological Activity of Some new 2-Heterocyclic/acyclic amino/4'-acetamidophenoxy-3-(4-chloro-phenyl)-3, 4-dihydrobenzo[e]- [1,3,2]oxazaphosphinine 2-sulfides

Author(s) -

K. R. Kishore Kumar Reddy,

Gandavaram Syam Prasad,

Manjeet Kumar,

C. Suresh Reddy,

C. Naga Raju

Publication year - 2007

Publication title -

journal of chemistry

Language(s) - English

Resource type - Journals

eISSN - 2090-9063

pISSN - 2090-9071

DOI - 10.1155/2008/415030

Subject(s) - triethylamine , chemistry , sodium hydride , tetrahydrofuran , toluene , medicinal chemistry , sulfide , organic chemistry , mass spectrum , antimicrobial , chloride , proton nmr , nuclear chemistry , solvent , ion

2-Heterocyclic/acyclicamino/4'-acetamidophenoxy-3-(4-chlorophenyl)-3,4-dihydrobenzo-[e][1,3,2]oxazaphosphinine 2-sulfides (4a-j) were synthesized through a two steps process. In the first step, 2-chloro-3-(4-chlorophenyl)-3, 4-dihydrobenzo[e] [1,3,2]-oxazaphosphinine 2-sulfide (2) was prepared by the reaction of 2-[(4-chlorophenylamino)methyl]phenol (1) with thiophosphoryl chloride in the presence of triethylamine in dry toluene-tetrahydrofuran. In the second step, 2 was treated with various heterocyclic/acyclicamines/4'-acetamidophenol in presence of triethylamine-/ sodium hydride in toluene-tetrahydrofuran at 45-50°C . All the synthesized compounds (4a-j) were characterized by elemental analysis, IR, NMR(1H, 13C and 31P) and mass spectra and their biological activity was evaluated for antimicrobial activity

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