Investigation of Zinc bis(1,4-didecylbenzo)-bis(2,3-pyrido) Porphyrazine for Application as Photosensitizer in Photodynamic Therapy of Cancer | Zendy

Keiichi Sakamoto | Zendy; Eiko OhnoOkumura | Zendy; T. Kato | Zendy; Masaki Watanabe | Zendy; Michael J. Cook | Zendy

Open Access

Investigation of Zinc bis(1,4-didecylbenzo)-bis(2,3-pyrido) Porphyrazine for Application as Photosensitizer in Photodynamic Therapy of Cancer

Author(s) -

Keiichi Sakamoto,

Eiko OhnoOkumura,

T. Kato,

Masaki Watanabe,

Michael J. Cook

Publication year - 2008

Publication title -

metal-based drugs

Language(s) - English

Resource type - Journals

ISSN - 0793-0291

DOI - 10.1155/2008/392090

Subject(s) - porphyrazine , chemistry , zinc , photosensitizer , dimethyl sulfate , photodynamic therapy , pyridine , medicinal chemistry , amphiphile , alkyl , photochemistry , organic chemistry , copolymer , polymer

The phthalocyanine analogue containing nonperipheral long alkyl-substituted benzenoid rings and pyridine rings, zinc bis(1,4-didecylbenzo)-bis(2,3-pyrido) porphyrazine, was synthesized. Zinc bis(1,4-didecylbenzo)-bis(2,3-pyrido) porphyrazine reacted with dimethyl sulfate and monochloroacetic acid to produce their quaternized products and diethyl sulfate to produce the sulfo-substituted products. All quaternized and sulfo-substituted showed amphiphilic character. Identical peaks in cyclic voltammograms appeared for these products before and after quaternization. During the evaluation of zinc bis(1,4-didecylbenzo)-bis(2,3-pyrido) porphyrazine for its photodynamic therapy of cancer (PDT) efficacy by cancer cell culture, the light exposed dimethyl sulfate quaternized zinc bis(1,4-didecylbenzo)-bis(2,3-pyrido) porphyrazines in IU-002 cells produce cell disruption that can be detected as a decrease in fluorescence.

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