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Background . Esophagectomy for esophageal cancer is being practiced routinely with favorable results at many centers. We sought to determine if tumor histology is a powerful surrogate marker for perioperative morbidity.  Methods . Seventy three consecutive patients managed operatively were reviewed from our prospectively maintained database.   Results . Adenocarcinoma (AC) was present in 52 (71%) and squamous cell (SCC) in 21 (29%). The use of neoadjuvant therapy was similar for the AC (34.62%) and SCC (42.86%) groups. The SCC group had a higher incidence of prior pulmonary disease than the AC group (23.8% versus 5.8%, resp.;  P  = .03). SCC patients were more likely to have a prolonged ICU stay than AC patients ( P  = .004) despite similar complication rates, EBL, and prognostic nutritional index. The SCC group did, however, experience higher grades of complications ( P  = .0053).  Conclusions . Presence of SCC was the single best predictor of prolonged ICU stay and more severe complications as defined by this study. Only a past history of pulmonary disease was different between the two histologic subgroups.

Esophageal Carcinoma Histology Affects Perioperative Morbidity Following Open Esophagogastrectomy