Anticancer Activity of Ag(I) N-Heterocyclic Carbene Complexes Derived from 4,5-Dichloro-1H-Imidazole | Zendy

Doug Medvetz | Zendy; K.M. Hindi | Zendy; Matthew J. Panzner | Zendy; Andrew J. Ditto | Zendy; Yang Yun | Zendy; Wiley J. Youngs | Zendy

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Anticancer Activity of Ag(I) N-Heterocyclic Carbene Complexes Derived from 4,5-Dichloro-1H-Imidazole

Author(s) -

Doug Medvetz,

K.M. Hindi,

Matthew J. Panzner,

Andrew J. Ditto,

Yang Yun,

Wiley J. Youngs

Publication year - 2008

Publication title -

metal-based drugs

Language(s) - English

Resource type - Journals

ISSN - 0793-0291

DOI - 10.1155/2008/384010

Subject(s) - carbene , imidazole , in vivo , hela , ovarian cancer , in vitro , chemistry , cell culture , cancer research , stereochemistry , combinatorial chemistry , cancer , biology , medicine , biochemistry , catalysis , genetics , microbiology and biotechnology

A class of Ag(I) N-heterocyclic carbene silver complexes, 1 – 3 , derived from 4,5-dichloro-1H-imidazole has been evaluated for their anticancer activity against the human cancer cell lines OVCAR-3 (ovarian), MB157 (breast), and Hela (cervical). Silver complexes 1 – 3 are active against the ovarian and breast cancer cell lines. A preliminary in vivo study shows 1 to be active against ovarian cancer in mice. The results obtained in these studies warrant further investigation of these compounds in vivo.

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