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A class of Ag(I) N-heterocyclic carbene silver complexes,  1 – 3 , derived from 4,5-dichloro-1H-imidazole has been evaluated for their anticancer activity against the human cancer cell lines OVCAR-3 (ovarian), MB157 (breast), and Hela (cervical). Silver complexes  1 – 3  are active against the ovarian and breast cancer cell lines. A preliminary in vivo study shows  1  to be active against ovarian cancer in mice. The results obtained in these studies warrant further investigation of these compounds in vivo.

Anticancer Activity of Ag(I) N-Heterocyclic Carbene Complexes Derived from 4,5-Dichloro-1H-Imidazole