Biological Signatures of Brain Damage Associated with High Serum Ferritin Levels in Patients with Acute Ischemic Stroke and Thrombolytic Treatment
Author(s) -
Mónica Millán,
Tomás Sobrino,
Juan F. Arenillas,
Manuel RodríguezYáñez,
Maria García-Gil,
Florentino Nombela,
Mar Castellanos,
Natàlia Pérez de la Ossa,
Patricia Cuadras,
Joaquı́n Serena,
José Castillo,
Antoni Dávalos
Publication year - 2008
Publication title -
disease markers
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.912
H-Index - 66
eISSN - 1875-8630
pISSN - 0278-0240
DOI - 10.1155/2008/380356
Subject(s) - medicine , ferritin , brain damage , stroke (engine) , ischemic stroke , brain ischemia , serum ferritin , cardiology , pathology , ischemia , mechanical engineering , engineering
Increased body iron stores have been related to greater oxidative stress and brain injury in clinical and experimental cerebral ischemia and reperfusion. We aimed to investigate the biological signatures of excitotoxicity, inflammation and blood brain barrier disruption potentially associated with high serum ferritin levels-related damage in acute stroke patients treated with i.v. t-PA.
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