Dorsolateral Prefrontal Cortex: A Possible Target for Modulating Dyskinesias in Parkinson′s Disease by Repetitive Transcranial Magnetic Stimulation | Zendy

Irena Rektorová | Zendy; Silvie Sedláčková | Zendy; Sabina Telecká | Zendy; Ales Hlubocky | Zendy; Ivan Rektor | Zendy

Open Access

Dorsolateral Prefrontal Cortex: A Possible Target for Modulating Dyskinesias in Parkinson′s Disease by Repetitive Transcranial Magnetic Stimulation

Author(s) -

Irena Rektorová,

Silvie Sedláčková,

Sabina Telecká,

Ales Hlubocky,

Ivan Rektor

Publication year - 2007

Publication title -

international journal of biomedical imaging

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.626

H-Index - 41

eISSN - 1687-4196

pISSN - 1687-4188

DOI - 10.1155/2008/372125

Subject(s) - transcranial magnetic stimulation , dorsolateral prefrontal cortex , neuroscience , prefrontal cortex , parkinson's disease , deep transcranial magnetic stimulation , stimulation , dorsolateral , medicine , physical medicine and rehabilitation , psychology , disease , cognition

We studied whether five sessions of 10 Hz repetitive transcranial magnetic stimulation (rTMS treatment) applied over the dorsolateral prefrontal cortex (DLPFC) or the primary motor cortex (MC) in advanced Parkinson's disease (PD) patients would have any effect on L-dopa-induced dyskinesias and cortical excitability. We aimed at a randomised, controlled study. Single-pulse transcranial magnetic stimulation (TMS), paired-pulse transcranial magnetic stimulation, and the Unified Parkinson's Disease Rating Scale (UPDRS parts III and IV) were performed prior to, immediately after, and one week after an appropriate rTMS treatment. Stimulation of the left DLPFC induced a significant motor cortex depression and a trend towards the improvement of L-dopa-induced dyskinesias.

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