Open AccessSynthesis and Characterization of New Diketone Analogues of Podophyllotoxin
Author(s) -
K. H. Hemakumar,
A. D. Sathisha,
Y.B. Basavaraju
Publication year - 2007
Publication title -
journal of chemistry
Language(s) - English
Resource type - Journals
eISSN - 2090-9063
pISSN - 2090-9071
DOI - 10.1155/2008/314724
Subject(s) - podophyllotoxin , characterization (materials science) , diketone , chemistry , combinatorial chemistry , stereochemistry , materials science , nanotechnology
The new compounds 6,6a-dihydro-2,3-dimethoxy-9-nitro-11bH benzo (C)-fluoren 5,7-dione, 6,6a-dihydro-2,3-dimethoxy-9-chloro-11bH benzo(C)-fluoren-5,7-dione and 6,6a-dihydro-2,3-dimethoxy-9-fluoro-11bH benzo(C)-fluoren-5,7- dione were synthesized in high yields. They are analogues of naturally occurring lignan podophyllotoxin which exhibits anticancer activity. They are very essential to study anticancer activity.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom