S100 Calgranulin Proteins S100A8, S100A9 and S100A12 are Expressed in the Inflamed Gastric Mucosa ofHelicobacter Pylori-Infected Children | Zendy

Steven T. Leach | Zendy; Hazel M. Mitchell | Zendy; Carolyn L. Geczy | Zendy; Philip M. Sherman | Zendy; Andrew S. Day | Zendy

Open Access

S100 Calgranulin Proteins S100A8, S100A9 and S100A12 are Expressed in the Inflamed Gastric Mucosa ofHelicobacter Pylori-Infected Children

Author(s) -

Steven T. Leach,

Hazel M. Mitchell,

Carolyn L. Geczy,

Philip M. Sherman,

Andrew S. Day

Publication year - 2008

Publication title -

canadian journal of gastroenterology

Language(s) - English

Resource type - Journals

eISSN - 1916-7237

pISSN - 0835-7900

DOI - 10.1155/2008/308942

Subject(s) - s100a9 , s100a8 , helicobacter pylori , gastric mucosa , gastritis , s100 protein , biology , inflammation , medicine , immunology , gastroenterology , stomach , immunohistochemistry

The expression of the inflammatory S100 calgranulin proteins (S100A8, S100A9 and S100A12) in normal and Helicobacter pylori-infected gastric mucosa of children were examined. S100A8, S100A9 and S100A12, which were virtually absent in normal gastric mucosa, were highly expressed in H pylori-infected mucosa. This expression correlated with the severity of gastritis (r=0.9422, P<0.05). S100 calgranulins may be involved in bacterial-induced gastritis and may limit bacterial growth.

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