Cationic Porphyrin Induced a Telomeric DNA to G-Quadruplex Form in Water
Author(s) -
Takashi Murashima,
Daichi Sakiyama,
Daisuke Miyoshi,
Masanori Kuriyama,
Takashi Yamada,
Toshifumi Miyazawa,
Naoki Sugimoto
Publication year - 2008
Publication title -
bioinorganic chemistry and applications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.865
H-Index - 35
eISSN - 1565-3633
pISSN - 1687-479X
DOI - 10.1155/2008/294756
Subject(s) - porphyrin , circular dichroism , cationic polymerization , tetrahymena , chemistry , g quadruplex , dna , biophysics , stereochemistry , crystallography , photochemistry , biochemistry , polymer chemistry , biology
The formation of the DNA G-quadruplex is induced by the addition of a novel porphyrin carrying four cationic tethers. Circular dichroism spectroscopy reveals that the porphyrin binds to Tetrahymena telomeric repeat to form G-quadruplex under stabilizing-cation-deficient and no buffer conditions.
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