Analysis of the alteration in the optical configuration of Raman spectrometer: Optimization of signal-to-noise ratio (SNR) in a specific wavelength range of clinical interest | Zendy

João Carlos Lázaro | Zendy; Carlos José de Lima | Zendy; Leonardo Marmo Moreira | Zendy; Landulfo Silveira | Zendy; Nelson José Freitas da Silveira | Zendy; Antônio Balbin Villaverde | Zendy; Marcos Tadeu Tavares Pacheco | Zendy

Open Access

Analysis of the alteration in the optical configuration of Raman spectrometer: Optimization of signal-to-noise ratio (SNR) in a specific wavelength range of clinical interest

Author(s) -

João Carlos Lázaro,

Carlos José de Lima,

Leonardo Marmo Moreira,

Landulfo Silveira,

Nelson José Freitas da Silveira,

Antônio Balbin Villaverde,

Marcos Tadeu Tavares Pacheco

Publication year - 2008

Publication title -

spectroscopy an international journal

Language(s) - English

Resource type - Journals

eISSN - 1875-922X

pISSN - 0712-4813

DOI - 10.1155/2008/294547

Subject(s) - spectrometer , signal to noise ratio (imaging) , raman spectroscopy , spectral resolution , distortion (music) , resolution (logic) , signal (programming language) , materials science , noise (video) , wavelength , optics , dynamic range , nuclear magnetic resonance , spectral line , computer science , physics , optoelectronics , artificial intelligence , amplifier , cmos , astronomy , image (mathematics) , programming language

The present article is focused on the optimization of the optical parameters of a Raman spectrometer in order to obtain a minimum width of its spectral lines. In this way, using as reference the width of a fingerprint band of a calcified biological tissue, a spectral line without distortion or any loss of resolution was identified. This optimization is employed with the aim of improvement of the signal-to-noise ratio (SNR). A great improvement in the efficiency of the spectral collect was obtained, which can reduce significantly the time of diagnosis of target tissues, such as the calcified coronarian tissue. Therefore, the potential application of this new spectroscopic system increases the efficiency and precision, favoring the security of this technique to future in vivo applications. The excellent results obtained in this work become this spectroscopic system a powerful tool to the clinical diagnosis of several diseases.

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