Peroxisome Proliferator‐Activated Receptor‐γ Is a Potent Target for Prevention and Treatment in Human Prostate and Testicular Cancer | Zendy

Masahide Matsuyama | Zendy; Rikio Yoshimura | Zendy

Open Access

Peroxisome Proliferator‐Activated Receptor‐γ Is a Potent Target for Prevention and Treatment in Human Prostate and Testicular Cancer

Author(s) -

Masahide Matsuyama,

Rikio Yoshimura

Publication year - 2008

Publication title -

ppar research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.164

H-Index - 49

eISSN - 1687-4765

pISSN - 1687-4757

DOI - 10.1155/2008/249849

Subject(s) - carcinogenesis , peroxisome proliferator activated receptor , cancer research , prostate cancer , receptor , cancer , flow cytometry , cancer cell , immunohistochemistry , mtt assay , apoptosis , biology , medicine , chemistry , microbiology and biotechnology , biochemistry

Peroxisome proliferator-activated receptor- γ(PPAR)- γis a ligand-activated transcriptional factor belonging to steroid receptor superfamily. PPAR- γplays a role in both adipocyte differentiation and tumorigenesis. Up to date, PPAR- γis expressed in various cancer tissues, and PPAR- γligand induces growth arrest of these cancer cells. In this study, we examined the expression of PPAR- γin prostate cancer (PC) and testicular cancer (TC) by RT-PCR and immunohistochemistry, and we also examined the effect of PPAR- γligand in these cells by MTT assay, hoechest staining, and flow cytometry. PPAR- γexpression was significantly more extensive and intense in malignant tissues than in normal tissues. PPAR- γligand induced the reduction of malignant cell viability through apoptosis. These results demonstrated that the generated PPAR- γin PC and TC cells might play an important role in the tumorigenesis. PPAR- γmay become a new target in the treatment of PC and TC.

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